Interactions of aminoquinolines and mepacrine with prostaglandins E2 in tissues of rats and guinea-pigs
Identifieur interne : 003908 ( Main/Exploration ); précédent : 003907; suivant : 003909Interactions of aminoquinolines and mepacrine with prostaglandins E2 in tissues of rats and guinea-pigs
Auteurs : D. T. Okpako [Nigeria]Source :
- General Pharmacology [ 0306-3623 ] ; 1978.
English descriptors
- Teeft :
- Amodiaquine, Appropriate concentration, Chloroquine, Contractile, Contractile responses, Dos, Higher concentrations, Histamine, Ileum, Inactivation, Mepacrine, Okpako, Olatunde, Perfused, Pge2, Pge2 inactivation, Pgez, Pharmac, Potentiating effect, Prostaglandin, Pulmonary circulation, Receptor, Stomach strip, Synthetase, Tyrode, Tyrode solution, Vane.
Abstract
Abstract: 1. The effects of two 4-aminoquinolines (chloroquine and amodiaquine) and mepacrine on the contractile effects of PGE2 in isolated muscle strips and on PGE2 inactivation in isolated lungs were investigated.2. The drugs inhibited PGE2-induced contractions of guinea-pig intestine but there was no evidence of specific interaction with prostaglandin receptors.3. On the rat stomach strip, and in concentrations lower than 1 μg ml−1, the drugs potentiated the effects of low doses of PGE2 but were without effect or inhibitory at higher concentrations.4. All three drugs inhibited PGE2 inactivation in rat lungs, amodiaquine being the most potent with an IC50 of 17 μg ml−1.5. Amodiaquine, but not chloroquine or mepacrine, moderately inhibited PGE2 inactivation in guinea-pig lungs.6. The results suggest species variation in characteristics of PGE2 inactivating mechanisms.
Url:
DOI: 10.1016/0306-3623(78)90053-8
Affiliations:
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Le document en format XML
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